down-regulate thrombomodulin transcription in vascular endothelial Oxidized phospholipids in oxidized low-density lipoprotein
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منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RAR -RXR heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter
The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (oxLDL). HUVECs exposed to phospholipid extracts, but not to free cholesterol, triglyceride, or cholesterol ester, isolated from ox-LDL reduced TM mRNA levels t...
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